Sildenafil Citrate's Impact on Intravaginal Ejaculatory Latency Time

They might have actions on the sensitivity of the penis, the muscles involved in ejaculation, or the nervous system.

Surgical Intervention

However, your healthcare provider sildenafil film tablet — likely a urologist — may treat premature ejaculation off-label with a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs. Research shows that SSRIs may help men last longer. For example, in one study from 1998, men affected by premature ejaculation who were treated with sertraline — an SSRI — observed an increase in their average ejaculatory interval (the amount of time before reaching orgasm and ejaculating) from one minute to a maximum of 16.4 minutes. Sertraline, the generic for Zoloft®, is one of the most widely used SSRIs for premature ejaculation. Other SSRIs prescribed by providers off-label to treat PE include: Like other SSRIs, sertraline can cause side effects. Our full guide to sildenafil and premature ejaculation goes into more detail about these treatments, as well as the potential benefits they may offer.

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In addition to sildenafil, other medications for treating ED include Avanafil (only available as brand name Stendra®) Avanafil (only available as brand name Stendra®) We offer numerous oral ED medications online, following a consultation with a licensed healthcare provider who will determine if a prescription is appropriate.

Section snippets

Having a physical or mental health condition that could cause PE — such as abnormal hormone levels or stress — puts you at an increased risk. Additionally, ED is sometimes considered a risk factor for PE. People with erectile dysfunction have difficulty getting or maintaining an erection that’s hard enough for satisfying sex. This could be a risk factor for PE because if you have ED, you might feel compelled to “rush” through sex in the hopes that your erection lasts the whole time, even if you aren’t conscious of doing so. The end result might be ejaculating much sooner than you'd like.

Desensitizing agents

Because the average time to ejaculate can vary so much from one man to another, PE can be a challenging condition to diagnose. To be diagnosed with premature ejaculation, you’ll typically need to have the symptoms listed above — such as rapid ejaculation after penetrating your partner and some level of distress due to your lack of ejaculatory control — and experience those symptoms consistently for at least six months. Your symptoms will also need to occur without a clear explanation, such as medication or drug use, a related medical condition, or an issue in your relationship that affects your sexual function and performance. In some cases, you may reach orgasm and ejaculate earlier than you’d like to, even if you don’t have clinical premature ejaculation. It’s not uncommon to ejaculate relatively quite quickly if you haven’t had sex in a long time. Premature ejaculation is often treatable using topical creams, sprays, and wipes that alter the sensitivity level of your penis. These products are designed for use before sex and contain topical anesthetics like lidocaine, benzocaine, or prilocaine.

• Sildenafil may enhance arousal and delay climax.
• The drug is not a cure for premature ejaculation.
• Overuse of sildenafil can lead to adverse effects.
• Combining sildenafil with alcohol can decrease effectiveness.
• Sexual timing and foreplay are natural PE remedies.
• Using sildenafil does not address orgasm control issues.
• Some men report increased confidence with sildenafil.
• The drug can cause priapism if misused.
• Psychological counseling can be beneficial for PE.
• Erectile health impacts PE treatment outcomes.
• Consistent use under medical supervision is recommended.

The ingredients are absorbed by the skin on your penis to limit sensitivity without affecting your partner. Research shows that sprays, wipes, and anesthetic creams for PE can slow down the process of reaching orgasm and ejaculating. One placebo-controlled study found that benzocaine wipes significantly increased time to ejaculation in men with premature ejaculation when applied to the penis before sex.

Tip	Explanation	Best Practice
Consult a healthcare professional	To determine appropriateness and safe dosage	Essential before starting treatment
Start with low dose	To minimize side effects and assess response	Usually 25-50 mg
Monitor and report side effects	To optimize treatment and safety	Follow-up appointments
Combine with behavioral therapy	Enhances overall outcomes	Address psychological factors

Unlike SSRIs and PDE5 inhibitors that require a prescription, most creams, sprays, and wipes for premature ejaculation are available over the counter.

Parameter	Value	Explanation
Absorption	Fast, begins within 30 min	Peak plasma concentration achieved in 1 hour
Bioavailability	~40%	Due to first-pass metabolism
Metabolism	Liver (CYP3A4 enzyme)	Adjust dose if on CYP3A4 inhibitors
Excretion	Feces (~60%), urine (~30%)	Slow process, affects timing of doses

Our Delay Spray for Men, which contains lidocaine, is available online as a convenient option for reducing sensitivity, which can help increase ejaculatory latency.

LinkOut - more resources

In this situation, it’s normal to feel more sexually aroused than usual and reach orgasm faster than you typically might because of it. It’s also common to feel as if you reach orgasm and ejaculate too fast, even if your ejaculatory latency time (the time it takes you to ejaculate) is within the normal range. During a consultation for PE, your healthcare provider may ask you about your sexual history to determine how long you’ve been affected by these symptoms. As we mentioned above, premature ejaculation can be lifelong (meaning it’s present since your first sexual encounter) or acquired (meaning it develops after some amount of normal sexual function). It can also occur generally or in certain situations, such as when you have sex with a specific partner.

Key Takeaways

If your healthcare provider asks you questions about your average time to ejaculation, “success rate” during sex, or about other factors that may play a role in ejaculation, try to answer them as clearly and honestly as you can. While ejaculation can be an embarrassing and awkward topic to discuss, keep in mind that your healthcare provider is there to help you — not to make any assumptions about your general sexual life or current relationship. The more information you can provide and the more accurately you can answer your provider’s questions, the more likely it is that they’ll be able to provide an accurate diagnosis, help you to overcome PE, and improve your sexual experiences. Although premature ejaculation can be frustrating to deal with, there are a variety of different techniques are used as treatments for premature ejaculation, including several types of medication, behavioral techniques, and counseling. Currently, there are no medications that are approved by the U.S Food and Drug Administration (FDA) specifically as treatments for premature ejaculation. We also offer Clockstopper Climax Delay Wipes, formulated with benzocaine.

Preparing for your appointment

However, there's no scientific backing to support either of these hypotheses. The reality is that researchers still aren’t sure what causes premature ejaculation to develop, nor is there a one-size-fits-all explanation for premature ejaculation and other forms of sexual dysfunction in men. Certain physical and biological factors may cause or contribute to premature ejaculation. Certain hormones, such as prolactin, luteinizing hormone (LH), and thyroid stimulating hormone (TSH) may contribute to premature ejaculation. Research suggests that low levels of the neurotransmitter serotonin may shorten the amount of time required to reach orgasm and ejaculate.

The pause-squeeze technique

Infections and/or inflammation that affect your prostate or urethra may affect your sexual function and contribute to premature ejaculation. Some experts also believe that the physical sensitivity level of your penis may play a role in the amount of time it takes for you to reach orgasm and ejaculate during sex. Research suggests that psychological factors may contribute to several different types of sexual dysfunction, including premature ejaculation. Premature ejaculation may also be caused by performance anxiety, a form of anxiety related to sexual performance that can also play a role in issues such as erectile dysfunction (ED). Just like researchers don’t exactly understand the causes of premature ejaculation, it can also be difficult to pinpoint the risk factors. Behavioral therapy involves identifying unhealthy or harmful behaviors and then taking meaningful steps to change them.

• Premature ejaculation can cause relationship issues.
• Education about sexual response helps reduce PE anxiety.
• Patience and communication improve sexual satisfaction.
• Biofeedback and behavioral therapy target PE.
• Some herbal supplements claim to help PE, but evidence is limited.
• Using sildenafil without medical guidance is risky.
• Emotional intimacy can reduce PE-related anxiety.
• Sleep quality impacts sexual performance and PE.
• PE treatment success varies among individuals.
• Peer support groups can provide helpful insights.
• Consistent treatment increases the likelihood of success.

When this type of therapy is used to treat sexual health issues like premature ejaculation, it’s often referred to as sex therapy.

• Early ejaculation is a normal variation for some men.
• Understanding personal sexual response helps manage PE.
• Sensory-enhancing devices may delay climax.
• Medications are not the only solution to PE.
• Regular exercise benefits erectile and ejaculatory health.
• Stress management techniques can improve PE outcomes.
• PE can be a sign of underlying medical issues.
• clinician-guided treatment yields better safety profiles.
• Support from partners encourages successful treatment.
• Combining therapy approaches often gives the best results.
• Healthy lifestyle choices support sexual function.

Behavioral therapy for PE may involve a combination of psychotherapy and physical techniques to delay or prevent ejaculation.

How ED and PE Are Connected: Exploring Shared Causes

You feel distressed because of your early ejaculation. You might feel less interested in having sex due to embarrassment or anxiety, feel like you have a low sex drive or feel as if your short time to ejaculate affects your general quality of life. However, it's important to remember that reaching orgasm and ejaculating quickly happens to everyone from time to time. To be considered premature ejaculation, these symptoms must occur during most or all sexual activity. Not all cases of ejaculating early are explicitly viewed as premature ejaculation.

RETRACTED ARTICLE: The effects of sildenafil citrate on intrauterine growth restriction: a systematic review and meta-analysis

For example, if you want to reach orgasm quickly during sex, this typically isn't considered a form of ejaculatory dysfunction. However, if you often ejaculate within a minute or two of penetration, feel unhappy or concerned about it, or simply feel as if you don’t have normal ejaculation control or sexual stamina, you could be affected by some form of premature ejaculation. Researchers believe that a range of factors could all contribute to premature ejaculation in certain ways, from physical factors to psychological ones. As with other sexual function issues (like erectile dysfunction), there are many widely shared — but scientifically inaccurate — “theories” about why PE develops in men. You may have read that premature ejaculation occurs when you don’t have sex on a frequent enough basis or are using the wrong bedroom techniques. Common physical techniques involve the “stop-start” approach, which involves stopping during sex to prevent orgasm and ejaculation, and then starting again after the urge goes away.

Counseling and Sex Therapy

We offer sertraline as a treatment for premature ejaculation online, following a consultation with a licensed healthcare professional who will determine if a prescription is appropriate for you. Research shows that some medications for erectile dysfunction may also help with premature ejaculation. Namely, these are the phosphodiesterase type 5 inhibitors (PDE5 inhibitors). For example, several studies have found that sildenafil, the active ingredient in Viagra® or generic Viagra, either increases ejaculatory latency time or improves sexual satisfaction and self-confidence in men affected by PE. There are several proposed mechanisms for how PDE5 inhibitors could help with PE. Another is the “squeeze technique", which involves squeezing the penis where the head meets the shaft during a pause in sex. You can learn more about these techniques and their effects in our guide to home remedies for premature ejaculation.

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