USE IN SPECIFIC POPULATIONS
«Source: Roger Clemens, host of athletes pop Viagra to help onfield performance». Pronunciation: sil-DEN-a-fil Generic name: sildenafil Brand names: Revatio, Viagra, Vybrique Dosage form: tablets (20 mg; 25 mg, 50 mg, 100 mg), injection (10 mg/12.5 mL), oral suspension (10 mg/mL), oral film (25 mg, 50 mg, 75 mg, 100 mg) Drug classes: Agents for pulmonary hypertension, Impotence medications Sildenafil is used to treat erectile dysfunction (ED) in adult men or pulmonary arterial hypertension (PAH) in adults and children, depending on the brand or formulation. Sildenafil tablets (25 mg, 50 mg, 100 mg; Viagra, generic) and sildenafil oral film (25 mg, 50 mg, 75 mg, 100 mg; Vybrique) are used for ED.
What should I do if I forget a dose?
«Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension». «Sildenafil for the treatment of altitude-induced hypoxaemia». Expert Opin Pharmacother 6 (5): 835-7. «Treatment of high altitude pulmonary edema at 4240 m in Nepal». ↑ «FDA Updates Labeling for Viagra, Cialis and Levitra for Rare Post-Marketing Reports of Eye Problems».
Erectile dysfunction
«Nonarteritic ischemic optic neuropathy developing soon after use of sildenafil (viagra): a report of seven new cases». «Sildenafil (Viagra) associated anterior ischemic optic neuropathy». «Sildenafil-associated nonarteritic anterior ischemic optic neuropathy». ↑ Cunningham; sildenafil citrate tables Cunningham AV and Smith KH (2001). «Anterior ischemic optic neuropathy associated with viagra».
Vybrique Oral Film
«A case of nonarteritic ischemic optic neuropathy (NAION) in a male patient taking sildenafil». «Case report: association of combined nonarteritic anterior ischemic optic neuropathy (NAION) and obstruction of cilioretinal artery with overdose of Viagra». ↑ «FDA Announces Revisions to Labels for Cialis, Levitra and Viagra». American College of Cardiology/American Heart Association». Journal of the American College of Cardiology 33 (1): 273-82. Sildenafil tablets (20 mg; Revatio, generic), sildenafil oral suspension (Revatio, generic), and sildenafil injection (Revatio, generic) are used for PAH.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 100mg | 20 Pills | 45.58€ 43.41€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Viagra Generic | 100mg | 270 + 10 Pills | 270.47€ 257.59€ | |
| Kamagra Soft Tabs | 100mg | 32 Pills | 120.11€ 114.39€ | |
| Viagra Generic | 25mg | 120 + 6 Pills | 125.56€ 119.58€ | |
| Viagra Generic | 100mg | 60 + 4 Pills | 96.36€ 91.77€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Kamagra Polo | 100mg | 180 + 8 Pills | 446.52€ 425.26€ | |
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ | |
| Viagra Generic | 50mg | 60 + 4 Pills | 83.93€ 79.93€ | |
| Viagra Generic | 50mg | 270 + 8 Pills | 198.48€ 189.03€ |
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, which breaks down cyclic GMP and enhances nitric oxide (NO) -mediated smooth muscle relaxation.
| Parameter | Value | Description |
|---|---|---|
| Absorption Time | 30-120 minutes | When the drug reaches peak plasma levels |
| Half-life | 3-5 hours | Time for plasma concentration to reduce by half |
| Metabolism | Liver (CYP3A4 enzyme) | Mainly processed by liver enzymes |
| Excretion | Feces and urine | Elimination pathways |
In erectile dysfunction (ED), this increases blood flow to penile tissue, facilitating an erection. In pulmonary arterial hypertension (PAH), it dilates pulmonary vessels by the same mechanism, reducing pulmonary blood pressure and improving exercise capacity. Sildenafil first gained FDA approval on March 27, 1998. Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas).
- Pfizer Sildenafil 100mg is often used when lower doses are ineffective.
- It can improve erectile response within 30-60 minutes.
- Do not crush or divide the tablet; swallow it whole.
- The medication should not be taken with heavy fatty meals.
- Ensure you have an adequate sexual partner for the medication to work.
The most common side effects of sildenafil tablets for ED are: Abnormal vision, such as changes in color vision (such as having a blue color tinge) andblurred vision The most common side effects of sildenafil oral film for ED are: Abnormal vision, such as changes in color and blurred vision The most common side effects of sildenafil tablets/ oral suspension, and injection for PAH are: Sildenafil can cause the following serious side effects. Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. Stop taking sildenafil and call your healthcare provider right away if you havesudden vision loss in one or both eyes. If you have these symptoms, stop taking sildenafil and contact a doctor right away.
Efectos farmacológicos e indicaciones
International Journal of Impotence Research 15 (3): 225-228. «The rise of Viagra among British illicit drug users: 5-year survey data». Drug and Alcohol Review 25 (2): 111-113. «Does marijuana use play a role in the recreational use of sildenafil?». Journal of Family Practice 56 (11): 932. In addition, heart attack, stroke, sildenafil oral solution irregular heartbeats, and death have happened rarely in people taking sildenafil. Most, but not all, of these people had heart problems before taking this medicine. It is not known if sildenafil caused these problems. Tell all your healthcare providers that you take sildenafil. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took sildenafil. Sildenafil does not protect you or your partner from getting sexually transmitted diseases, including Human Immunodeficiency Virus (HIV). Sildenafil may cause low blood pressure, which may cause you to feel faint or dizzy. Lie down if you feel faint or dizzy. Tell your doctor if you get more short of breath after you start sildenafil. More shortness of breath than usual may be due to your underlying medical condition.
5.6 Adverse Reactions with the Concomitant Use of Ritonavir
As always, please feel free to reach out to our McGuff Customer Service team with any questions that you may have. ↑ Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, Gingell C (June 1996). «Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction». ↑ Boolell; Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, Gingell C (1996). «Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction».
Effectiveness and safety
Health Aff (Millwood) 19 (2): 147-57. «Sales of Impotence Drugs Fall, Defying Expectations». ↑ «Viagra patent expires in June, says Brazilian court». ; Freestone, S.; Allen, M.J.; Muirhead, G.J. «Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist».
Drug details
«Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus». «Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial». «Sildenafil for women patients with antidepressant-induced sexual dysfunction». «Sildenafil Treatment of Women With Antidepressant-Associated Sexual Dysfunction». «FDA Approves Pfizer's Revatio as Treatment for Pulmonary Arterial Hypertension». Do not take Viagra while also taking Revatio.
- Pfizer Sildenafil 100mg offers a quick onset of action for most users.
- It’s advisable to try the medication in a comfortable setting.
- Sildenafil is effective for many men with ED but not for everyone.
- The drug is often prescribed after other treatments have failed.
- It’s important to discuss all health issues with your healthcare provider.
These are not all of the possible side effects of sildenafil. You may report side effects to the FDA at 1-800-FDA-1088. Have allergies to sildenafil, Viagra, Revatio, Vybrique, or any of the ingredients in the sildenafil formulation you are taking Take other medicines for pulmonary arterial hypertension, such as riociguat (Adempas) Take other medicines for pulmonary arterial hypertension, such as riociguat (Adempas) Take other medicines that lower your blood pressure, such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs that also contain nitrates, such as "poppers". To make sure sildenafil is safe for you, tell your healthcare provider about all your medical conditions, including if you have: Or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure Had heart surgery within the last 6 months Low blood pressure, or high blood pressure that is not controlled A physical deformity of the penis (such as Peyronie's disease) Been told you should not have sexual intercourse for health reasons and you are a male Had an erection that lasted for more than 4 hours Problems with your blood cells, such as sickle cell anemia, multiple myeloma, or leukemia Retinitis pigmentosa, a rare genetic (runs in families) eye disease Ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) Kidney problems or are having kidney dialysis Are pregnant or intending to become pregnant (for patients with PAH) Are breastfeeding or intending to breastfeed (for patients with PAH). Sildenafil for ED is not approved for males <18 years old.
- Sildenafil 100mg is contraindicated in patients with recent stroke or heart attack.
- Take sildenafil on an as-needed basis; daily use is not recommended.
- The medication does not cause automatic erections without sexual arousal.
- Be aware of potential side effects like sudden vision loss.
- Confirm your health history with your healthcare provider before use.
Sildenafil is not expected to harm an unborn baby.
- Pfizer Sildenafil 100mg is used to treat erectile dysfunction in men.
- It works by increasing blood flow to the penis.
- The medication is typically taken about an hour before activity.
- Possible side effects include headaches, flushing, and dizziness.
- Consult your doctor before using Pfizer Sildenafil 100mg.
Tell your doctor if you are pregnant or plan to become pregnant.
Understanding Sildenafil
«Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions». ↑ R. Baselt: Disposition of toxic drugs and chemicals in man (págs. Foster City (California): Biomedical Publications, octava edición, 2008. ↑ Oh S.
Does Viagra help with premature ejaculation?
S., Zou P., Low M. Y., Koh H. L.: «Detection of sildenafil analogues in herbal products for erectile dysfunction», en Journal of Toxicology and Environmental Health (part A). ↑ Venhuis B. J., Blok-Tip L., De Kaste canada sildenafil D.: «Designer drugs in herbal aphrodisiacs», en Forensic Science International.
Does Viagra increase the size of a man’s penis?
«Young men add Viagra to their drug arsenal». «Recreational use and misuse of phosphodiesterase 5 inhibitors». Journal of the American Pharmacists Association 45 (1): 63-75. doi:10.1331/1544345052843165. «Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time». Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor if they discover they are pregnant. It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breastfeeding a baby.
| Country | Approval Status | Regulatory Agency | Notes |
|---|---|---|---|
| USA | Approved | FDA | Prescribed for ED |
| UK | Approved | MHRA | Licensed medication |
| Canada | Approved | Health Canada | Available by prescription |
| Australia | Approved | TGA | Prescription required |
Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor. Take sildenafil oral tablets exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much to take and when to take it. You may take sildenafil between 30 minutes to 4 hours before sexual activity if needed. If you take sildenafil after a high-fat meal (such as a cheeseburger and fries), sildenafil may take a little longer to start working.
Copyright
Unless otherwise stated, the "Person responsible for the content" holds all text rights. The image rights belong either to the "Person responsible for the content" or to Webbaumeister or their partners.
Availability
The provider of this website and the Web agency Webbaumeister (Basel, Winterthur), their partner for professional web design and search engine optimization, do everything possible to ensure maximum availability of this website.