URETHRAL GEL
17 using Student-t-test and Fisher's exact test for comparing
Uses / Indications
Study design:~This is a prospective self-controlled clinical trial.~Study subjects:~Investigators counseled and recruited 42 infertile women who had been diagnosed with anovulatory infertility, with normal baseline FSH, LH, and free testosterone levels, patent tubes on hysterosalpingography, and normal male semen analysis.~By the time they were enrolled in the study, all women had already completed 5 ovulatory cycles of Clomiphene citrate induction (in a dose of 100 mg/ day in two divided doses starting from day 3 of the cycle for 5 days) but without conception (clomiphene citrate failure) with thin endometrium (\<8mm) in at least 3 cycles. Ovulation was documented sonographically, and with day-21 serum progesterone exceeding 5 ng/ ml in all cases.~Exclusion criteria:~Women with major medical problems, male factor infertility, endocrine abnormalities such as hyperprolactinemia or abnormal thyroid functions, prior ovarian or adnexal surgery, or organic pelvic pathology were not included in the study.~Intervention:~Sixth cycle (Clomiphene citrate only):~Enrolled cases were asked to continue with Clomiphene citrate induction ( at the same dose) for the 6th cycle. A gel base, without medicament (vehicle only), was applied vaginally in a dose of 5 gm twice per day, from cycle day 8 to the day of HCG administration ( when follicular diameter reached 18 mm). Endometrial thickness and Uterine artery Doppler assessment were done in the late proliferative phase ( Day of HCG injection).~Seventh cycle ( Sildenafil vaginal gel and Clomiphene cycle):~Those who didn't conceive on the sixth cycle (41 women) were asked to have an extra (7th) cycle in which they were prescribed the usual dose of Clomiphene citrate in addition to sildenafil vaginal gel. The dose was 5 g gel containing 50 mg sildenafil, applied vaginally twice daily from cycle day 8 to Day of HCG injection. data in the 6th and 7th cycles, as appropriate.
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Reviewed by Howard E.
- Some clinical studies suggest sildenafil gel causes less headache than oral forms.
- Topical application reduces systemic blood concentrations, minimizing cardiovascular risks.
- The gel form is especially suitable for patients with gastrointestinal issues.
- Use with caution in patients with certain dermatological diseases.
- Consult a physician before switching from oral to topical sildenafil formulations.
- Regular follow-ups help adjust dosage and monitor effectiveness.
- Use in women is not well studied and generally not recommended.
LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory
| Condition | Details | Reason |
|---|---|---|
| Temperature | 2°C to 25°C | Prevent degradation |
| Humidity | Below 60% | Avoid microbial growth |
| Light Exposure | Store in opaque container | Protect from photodegradation |
| Shelf Life | 24 months | Ensure efficacy over shelf life |
Board Member, Harvard Health Publishing Men will soon have a new option for treating erectile dysfunction (ED) that supposedly works faster
- Sildenafil gel absorption bypasses the digestive system, preventing first-pass metabolism.
- Topical application potentially reduces drug interactions compared to oral intake.
- It may be less effective for severe erectile dysfunction cases compared to oral tablets.
- User satisfaction depends largely on individual response and ease of use.
- The gel form could be more discreet for spontaneous sexual activity.
- Prescription requirements vary by country for sildenafil gel products.
- It is essential to confirm product authenticity to avoid counterfeit gels.
than regular ED medication — and is available without a prescription.
1. Introduction
The 10 mg/g concentration allows for precise dosing, and the gel form ensures that the medication is evenly distributed across the vaginal mucosa. This formulation can be particularly useful for patients who may not tolerate oral sildenafil due to gastrointestinal side effects or those who require localized treatment for specific gynecological issues. Patients using Sildenafil Citrate 10 mg/g Vaginal Gel should follow the application instructions provided by their healthcare provider to ensure optimal results. It is recommended to apply the gel as directed, typically before sexual activity, to allow sufficient time for the medication to take effect. Patients should be aware of potential side effects, such as local irritation or allergic reactions, and report any adverse effects to their healthcare provider.
2.9. Ex Vivo Skin Permeation Studies
If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your health and treatment options. Sildenafil Citrate 10 mg/g Vaginal Gel, while primarily formulated for specific gynecological purposes, may have other potential uses that could be of interest to both patients and prescribers. This gel-like semisolid formulation is designed for easy and controlled application in the vaginal area, which allows for localized delivery of medication. Beyond its primary indications, this formulation may be explored for its potential benefits in enhancing sexual function by increasing blood flow to the vaginal tissues, which could improve lubrication and sensitivity, potentially benefiting individuals experiencing sexual dysfunction or discomfort during intercourse. In June, the FDA approved the over-the-counter sale of MED3000 (Eroxon), a topical gel treatment for ED.
Interactions of Vega Oral Jelly
The gel was prepared in collaboration with the department of pharmaceutics, faculty of Pharmacy, Assiut University. Sixty grams of gel were prepared in tubes and every patient was given 10 applicators like that used for administration of vaginal antimycotic creams to use them for applying the gel.~Evaluation of the study end points:~On day of HCG injection (main follicular diameter of 18 mm) in the 6th, and 7th cycles, women came for follow up and had transvaginal sonographic assessment of their endometrial thickness. In addition, Transvaginal Doppler examination was also done on the same visit to evaluate the pulsatility indices of both uterine arteries. When the leading follicle reached 18 mm in diameter, 5000 IU of HCG was prescribed for IM injection.~Although pregnancy rate was not a primary outcome measure in the study, investigators detected pregnancy in 3 cases in the cohort of 36 cases of infertile women with clomiphene failure in which sildenafil gel was added as an adjuvant. Pregnancy was diagnosed with a B-HCG value above 100 mIU/ml, and confirmed later with ultrasound.~Statistics:~Data were analyzed using SPSS program ver. MED3000 is supplied in single-use tubes.
What should I know about storage and disposal of this medication?
Typically, it is dispensed from a tube and applied directly to the vaginal area for optimal therapeutic effects. You should consult your healthcare provider before using this gel if you are pregnant or breastfeeding to ensure it is safe for you and your baby. Some users may experience mild irritation or discomfort. If you experience severe side effects or an allergic reaction, discontinue use and consult your healthcare provider immediately. The frequency of use should be determined by your healthcare provider based on your specific needs and condition.
2.8. Evaluation of SDF-BS Gel
Before using this gel with other vaginal products, consult your healthcare provider to avoid potential interactions or reduced effectiveness. Store the gel at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets. If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. The contents are rubbed onto the head of the penis immediately before sexual intercourse.
Diet & Lifestyle Tips
Additionally, the vasodilatory effects of Sildenafil Citrate might be investigated for their potential to alleviate symptoms associated with certain pelvic conditions, such as pelvic congestion syndrome, where increased blood flow could help reduce discomfort. The gel formulation also offers a unique advantage in providing a soothing and lubricating effect, which may be beneficial for individuals experiencing vaginal dryness or irritation, whether due to hormonal changes, menopause, or other factors. This could improve overall vaginal health and comfort, making it a versatile option for those seeking relief from such symptoms. Furthermore, the localized application minimizes systemic absorption, potentially reducing the risk of systemic side effects commonly associated with oral administration of Sildenafil. This makes it a potentially safer alternative for individuals who may be sensitive to systemic effects or who are taking other medications that could interact with oral Sildenafil.
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
As with any medication, it is important for patients and prescribers to discuss the potential benefits and risks, considering individual health conditions and treatment goals. If you have any questions or need further information, please reach out to us at Bayview Pharmacy. This gel is used for delivering medication or providing lubrication and therapeutic effects for various gynecological purposes. It is specifically formulated for easy and controlled application in the vaginal area. The gel should be applied as directed by your healthcare provider. The gel contains a combination of volatile solvents which, when applied to the head of the
- The gel allows easier dose adjustment compared to fixed-dose tablets.
- Some patients prefer the non-invasive nature of gel application.
- Patient counseling addresses realistic expectations from topical sildenafil.
- Use on damaged skin should be strictly avoided to prevent systemic absorption spikes.
- Can be incorporated into broader male sexual health management.
- Clinical effectiveness depends on consistent and correct application.
- Discreet packaging aids in user privacy and compliance.
penis, evaporate rapidly, stimulating nerve endings through an
| Ingredient | Concentration | Purity (%) | Solvent Used | pH Level | Preservatives |
|---|---|---|---|---|---|
| Sildenafil Citrate | 10 mg/g | 99.5 | Propylene Glycol | 5.5 | Methylparaben |
| Glycerin | -- | -- | -- | -- | -- |
| Carbomer | 1.5% | -- | -- | -- | -- |
| Ethanol | 2% | -- | -- | -- | -- |
| Purified Water | q.s. to 100g | -- | -- | -- | -- |
initial cooling effect, followed by a warming sensation.
In case of emergency/overdose
Thoroughly pulverize the required number of sildenafil tablets for the prescription. (A high-speed mill/coffee grinder works well.) Add the propylene glycol and purified water to the sildenafil citrate powder, and form a smooth paste. Incorporate into sufficient hydrophilic ointment (Dermabase, Vanicream) to final weight and mix well. Warm the purified water to about 70°C and add to the powder-propylene glycol mixture. Package in tight, light-resistant containers.1 A beyond-use date of 14 days can be used for this preparation when stored in a refrigerator.1 Sildenafil cream and sildenafil gel have been used to improve uterine artery flow and endometrial development in patients undergoing in vitro fertilization. This reaction releases nitric oxide, relaxing the smooth muscle tissue inside the
What side effects can this medication cause?
Yes, a prescription sildenafil premature ejaculation is typically required for this medication. Consult your healthcare provider to determine if it is appropriate for you. This gel is specifically formulated for vaginal use and is not intended for use by men. Consult a healthcare provider for appropriate treatments for male conditions. Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety.
Who should not take sildenafil?
The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.No compounded medications are reviewed by the FDA for safety or efficacy. No compounded medications are reviewed by the FDA for safety or efficacy. Calculate the required quantity of each ingredient for the total amount to be prepared. Accurately weigh and/or measure each ingredient. penis and increasing blood flow that is needed to obtain an erection.
| Feature | Gel | Tablet | Comment |
|---|---|---|---|
| Speed of Absorption | Faster | Slower | Gel bypasses GI tract |
| Convenience | Easy to apply directly | Swallowed whole | Discreet use |
| Dosage Flexibility | Customizable per application | Fixed doses | Better for dose titration |
| Side Effects | Lower GI irritation | More systemic exposure | Reduced gastrointestinal side effects |
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